Snake bites and bee stings: the mast cell strikes back
Article Abstract:
The mast cell, an immune cell known to be involved in allergic reactions, is commonly thought to contribute to anaphylaxis and damage after snake bites and bee stings, but studies indicate that these cells instead mount a defense against venom and inactive toxins. A study by scientists shows that mast cells can defend against envenomation rather than promote its pathological consequences by releasing proteases and other products that chew up and neutralize the major toxins of snake or bee venoms or diminish the toxin's adverse effects.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Inhibition of Fc[epsilon]RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes
Article Abstract:
ES-62 is a highly purified and endotoxin-free molecule that is secreted by filarial nematodes. Experiments confirm its role in inhibiting mast cell responses mediated by the Fc[epsilon] receptor (Fc[epsilon]RI).
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Mast cells promote antherosclerosis by releasing proinflammatory cytokines
Article Abstract:
Studies conducted establish the direct participation of mast cells and mast cell-derived interleukin-6 and interferon-[gamma] in mouse atherogenesis in low-density lipoprotein receptor-deficient mice.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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